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DTSTART;TZID=Europe/Berlin:20250507T123000
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DTSTAMP:20250505T094602Z
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UID:8119-1746621000-1746626400@www.crc1382.org
SUMMARY:'Gut\, Liver and Friends' Seminar with Charlotte Scott
DESCRIPTION:On Wednesday\, 07.05.2025 at 12:30\, Charlotte Scott from VIB-UGent Center for Inflammation Research\, Belgium\, will be the speaker of our ‘Gut\, Liver and Friends‘ seminar. \nThe title of her presentation is: \n“Investigating hepatic macrophage heterogeneity in health and disease“
URL:https://www.crc1382.org/event/gut-liver-and-friends-seminar-with-charlotte-scott/
LOCATION:Lecture Hall 6\, UK Aachen\, Pauwelsstr. 30\, Aachen\, 52074
CATEGORIES:Gut, Liver and Friends Seminar
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BEGIN:VEVENT
DTSTART;TZID=Europe/Berlin:20250521T123000
DTEND;TZID=Europe/Berlin:20250521T140000
DTSTAMP:20250513T150613Z
CREATED:20250513T150613Z
LAST-MODIFIED:20250513T150613Z
UID:8204-1747830600-1747836000@www.crc1382.org
SUMMARY:'Gut\, Liver and Friends' Seminar with Matthew Mangan
DESCRIPTION:On Wednesday\, 21.05.2025 at 12:30\, Matthew Mangan from the Institute of Medical Microbiology at Cologne University Hospital will be the speaker of our ‘Gut\, Liver and Friends‘ seminar. \nThe title of his presentation is: \n“Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation“ \n\nDetecting noxious molecules within the endo/lysosomal system is essential for maintaining cellular integrity. Here\, we identify acute cytosolic sodium accumulation as a key trigger for NLRP3 inflammasome activation. Large clostridial toxins\, as well as monosodium urate and silica crystals\, rapidly elevate cytosolic sodium by promoting its release from the endo/lysosomal system\, triggering potassium efflux and subsequent extracellular sodium influx. This rise in cytosolic sodium disrupts endocytic trafficking by collapsing the sodium gradient across endosomal membranes\, leading to peripheral redistribution and activation of NLRP3. Importantly\, non-particulate stimuli\, including nigericin\, also activate NLRP3 by this sodium-dependent mechanism. These findings position cytosolic sodium as a key downstream effector of potassium efflux and a central signal for NLRP3 activation across diverse stimuli.
URL:https://www.crc1382.org/event/gut-liver-and-friends-seminar-with-matthew-mangan/
LOCATION:Lecture Hall 6\, UK Aachen\, Pauwelsstr. 30\, Aachen\, 52074
CATEGORIES:Gut, Liver and Friends Seminar
ORGANIZER;CN="Joel Selkrig":MAILTO:jselkrig@ukaachen.de
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DTSTART;TZID=Europe/Berlin:20250522T140000
DTEND;TZID=Europe/Berlin:20250522T170000
DTSTAMP:20250514T090925Z
CREATED:20250514T090925Z
LAST-MODIFIED:20250514T090925Z
UID:8212-1747922400-1747933200@www.crc1382.org
SUMMARY:Speeddate with the Doctoral Thesis
DESCRIPTION:The CRC 1382 presents itself at the event “Speeddate with the Doctoral Thesis” which takes place on May 22nd between 2 and 5 pm in the large seminar room of the UK Aachen. \nThe event is organized by the medical student council. It is aimed at providing insight into current research projects at the UK Aachen\, promoting exchange between potential junior researchers and experienced scientists and recruiting doctoral students. \nAnyone interested in finding out more about our research at the CRC or pursuing a doctoral thesis in the field of the gut-liver axis is cordially invited! CRC representatives from various research fields will talk to you at our stand in a relaxed atmosphere and answer your questions.
URL:https://www.crc1382.org/event/speeddate-with-the-doctoral-thesis/
LOCATION:large seminar room\, Pauwelsstr. 30\, Aachen\, Germany
CATEGORIES:Public Outreach
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