Prof. Julia Stingl, the newly recruited director of the Institute of Clinical Pharmacology at RWTH Aachen University, was our seminar guest on 4thof March 2020.
Julia Stingl talked about ‘The Pharmacological Gut-Liver Interaction: Implications on Personalized Drug Therapy and Dosing’. She introduced us in the importance of personalized therapeutics due to an individualized expression of so called ‘pharmacogenes’ which play a big role in drug uptake and metabolization. Beside the patient´s genetics, the microbiota of the patient could have a major impact due to the huge diversity of genes provided by the commensals which can have an important influence on the uptake, bioavailability and processing of drugs.
Huebner T, Steffens M, Linder R, Fracowiak J, Langner D, Garling M, Falkenberg F, Roethlein C, Gomm W, Haenisch B, Stingl J. Influence of metabolic profiles on the safety of drug therapy in routine care in Germany: protocol of the cohort study EMPAR. BMJ Open. 2020 Apr 27;10(4):e032624. doi: 10.1136/bmjopen-2019-032624.
van der Wouden CH, Böhringer S, Cecchin E, Cheung KC, Dávila-Fajardo CL, Deneer VHM, Dolžan V, Ingelman-Sundberg M, Jönsson S, Karlsson MO, Kriek M, Mitropoulou C, Patrinos GP, Pirmohamed M, Rial-Sebbag E, Samwald M, Schwab M, Steinberger D, Stingl J, Sunder-Plassmann G, Toffoli G, Turner RM, van Rhenen MH, van Zwet E, Swen JJ, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium. Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study. Pharmacogenet Genomics. 2020 Apr 20. doi: 10.1097/FPC.0000000000000405. [Epub ahead of print]