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Understanding and Modelling processes
that constitute the Gut-Liver Axis

A comprehensive knowledge will foster the development of innovative diagnostic
tools and interventional strategies to improve patient care.

Research

Gut and Liver Functions are Characterized by Organ Crosstalk

Gut and Liver develop from a common cellular ancestor. Gut and Liver cooperate in nutrient uptake and metabolism. Gut and Liver structurally and functionally separate the microbiota-containing gut lumen from the systemic circulation. Gut and Liver act in concert to ensure tolerance to the microbiota and dietary antigens. And last but not least, Gut and Liver provide immunity to pathogens. The functional link between gut and liver is immediately visible in clinical medicine and results in a number of combined disease manifestations.

Our goal is a comprehensive understanding and modelling of the Gut-Liver Axis. This will foster the development of innovative diagnostic tools and interventional strategies and improve patient care.

To Research

Scientists

We are a team of basic and clinician scientist. Based at the RWTH Aachen University and partners in Leipzig, Bonn and Berlin our expertise is focused around gastroenterology, microbiology, immunology and bioinformatics. We are collaborating to bridge the gap between basic research and clinical needs.

To Scientists

Publications

A good measure of productive scientific cooperation within CRC1382 is our publication record.

Scientists in the consortium regularly report their findings in international peer reviewed journals, on scientific conferences and in the public press.

To Publications

Career

We support for basic and clinician scientists at all stages of their careers.

Doctoral candidates work on major aspects of the projects. They are enrolled in the associated Graduate school ‚Gut-Liver Axis that provides a structured environment ensuring optimal support of the project.

Bachelor and Master students contribute to exciting projects embedded in the CRC1382. Postdocs will be supported in developing their own projects and becoming independent scientists.

We provide multifaceted job opportunities and strongly encourage unsolicited applications!

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News and Activities

We discuss and communicate scientific data and concepts via regular seminars, retreats and publications.

  1. RDM
  2. Marie-Christine Simon

    October 7 @ 15:30 - 16:30
  3. Sebastian Zeißig

    October 14 @ 17:15 - 18:15
  4. 2nd Retreat of CRC1382

    October 15 - October 16
To events
To the news archive

Contact to the speaker

Spokesperson CRC 1382

Prof. Dr. rer. nat. Oliver Pabst
Institute of Molecular Medicine,
RWTH Aachen University

Necla Özaydin
RWTH Aachen University
Pauwelsstraße 30
52074 Aachen, Germany

+49 241 80-85686

Fax.: +49 241 80-82094

noezaydin@ukaachen.de

gutliveraxis@ukaachen.de

www.ukaachen.de

Dr. rer. nat. Heike Herbrand

hherbrand@ukaachen.de

Steering Committee

Priv. Doz. Dr. med. Marie-Luise Berres
Department of Internal Medicine III,
RWTH Aachen University

Prof. Dr. rer. nat. Thomas Clavel
Institute of Medical Microbiology,
RWTH Aachen University

Prof. Dr. med. Mathias W. Hornef
Institute of Medical Microbiology,
RWTH Aachen University

Prof. Dr. med. Fabian Kiessling
Institute for Experimental Molecular Imaging,
RWTH Aachen University

Prof. Dr. med. Christian Trautwein
Department of Internal Medicine III,
RWTH Aachen University

Prof. Dr. rer. nat. Oliver Pabst
Institute of Molecular Medicine,
RWTH Aachen University

Involved institutions

A core team of basic and clinician scientists from RWTH Aachen University is strengthened by experts
from Charité (Berlin), Goethe University (Frankfurt), Helmholtz Centre for Environmental
Research (Leipzig) and Maastricht University. CRC1382 is funded by the
Deutsche Forschungsgemeinschaft.

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