Gut and Liver Functions are Characterized by Organ Crosstalk
Gut and Liver develop from a common cellular ancestor. Gut and Liver cooperate in nutrient uptake and metabolism. Gut and Liver structurally and functionally separate the microbiota-containing gut lumen from the systemic circulation. Gut and Liver act in concert to ensure tolerance to the microbiota and dietary antigens. And last but not least, Gut and Liver provide immunity to pathogens. The functional link between gut and liver is immediately visible in clinical medicine and results in a number of combined disease manifestations.
Our goal is a comprehensive understanding and modelling of the Gut-Liver Axis. This will foster the development of innovative diagnostic tools and interventional strategies and improve patient care.