A04: Molecular signatures underlying gut-liver crosstalk in health and disease

The portal vein connects gut and liver, and mediators entering the portal vein have far-reaching consequences on liver function.

In this project we will:

  • employ non-targeted proteomics and targeted metabolomics to identify mediators of gut-liver crosstalk in portal vein blood
  • align these molecular signatures with clinical imaging and radiomic signatures of gut barrier integrity and liver health
  • perform bioassays to define their functional significance
  • identify distinct mediators of the gut-liver axis in systemic circulation

Combined, we will identify and characterize novel mediators to better understand and diagnostically assess clinically relevant changes within the human gut-liver axis.

Mass spectrometric analysis of plasma samples

Functional magnetic resonance imaging (MRI) of liver and gut

Involved scientists

Publications within Project A04