CRC 1382 is organized in two main projects areas.
In project area A, ‘Microbiota and metabolic pathways’, we aim at defining the mechanisms of how gut-liver interactions impact metabolism in health and disease. In nine projects we study the interactions between microbiota, microbial and host metabolism and the stroma in order to decipher their contributions to intestinal and hepatic diseases.
In project area B, ‘Immunological circuits’, we focus on immune cell-mediated aspects of the gut-liver axis. Immunological mechanisms are evolutionarily fundamental for proper metabolic functions of the gut-liver axis and control of the microbiota. At the same time, host-microbe interactions need to ensure effective defence mechanisms against pathogens. Thus, an improved understanding of immunological mechanisms within the gut-liver axis is crucial.
Project areas A and B are complemented by two scientific service projects, Q01 (in vivo imaging) and Q02 (functional microbiota analysis). Core project Q03 houses the CRC1382 associated graduate school ‘Gut-Liver Axis’. Administrative core project Q04 is dedicated to central tasks of the CRC.