…deciphering immune cell-mediated aspects of the gut-liver axis…
Projects in this area consider homeostasis and malfunctions of the gut-liver axis as the interplay between immune cells, microbiota, metabolism and other environmental factors.
B01 dissects dynamic changes in the gut-liver axis during postnatal development.
B02 studies the link between immune cell migration and hepatic manifestations of intestinal diseases.
B04 focusses on the roles of dendritic cells in homeostasis as well as in patients with chronic liver disease and impaired intestinal barrier functions.
B05 characterizes the consequences of gut-derived molecular signals on the origin and function of hepatic macrophages.
B06 studies the interrelation between hepatic and intestinal IgA producing plasma cells.
B07 explores the capacity of the gut-liver axis in limititing translocation of bacteria and the risk of sepsis in patients with decompensated liver cirrhosis.
B08, a new project initiated in the 2nd funding period, analyzes the influence of gut-derived factors on liver during cancer.
B09, another new project initiated in the 2nd funding period, dissects microbiota-dependent and -independent functions of inflammasome-mediated immunity during Hepatocellular Carcinoma development.
B03 will not be not continued in the second funding period.