Within CRC 1382 we encourage collaborations between different areas of research and disciplines. The result of such a joint venture is visible in the latest publication MAdCAM-1/a4b7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice by our PIs Angela Schippers, Norbert Wagner (both B02) and Frank Tacke (B05). It is not only a transdisciplinary effort but also builds a bridge between Aachen and Berlin.
In this collaboration the authors subjected immunocompetent or lymphopenic mice with deficiencies in either β7 integrin or MAdCAM-1 to concanavalin A-induced hepatitis. By evaluation of disease progression and in vivo monitoring of lymphocyte motility, they come to the conclusion that α4β7/MAdCAM-1 lymphocyte/endothelial interactions promote acute immune-mediated experimental hepatitis and that reduced motility and increased adhesion of lymphocytes in the liver sinusoids is mediated by MAdCAM-1.
Moreover, they identified an additional role of β7 integrin on innate immune cells in contributing to concanavalin-A mediated MAdCAM-1 expression and its inflammatory consequences.
If you like to take a closer look at the results you can access the pre-print version of the open access article via 10.1016/j.jcmgh.2020.12.003.