New CRC publication in PNAS:
Salmonella infection accelerates postnatal maturation of the intestinal epithelium
The postnatal establishment of metabolic, host–microbial, and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Tissue damage during this “neonatal window of opportunity” may disrupt these processes explaining human epidemiological data associating early life events with persistent adverse effects on mucosal physiology, host metabolism, growth, and intellectual development. Lead by Dr. Aline Dupont and Prof. Mathias Hornef, Stefan Schlößer (former PhD student) and Anna-Lena Ullrich (current PhD student) show that early life enteric infection induces an accelerated tissue maturation and the premature emergence of antimicrobial, metabolic, developmental, and regenerative properties of the adult gut. Several technical aspects of the research were carried out through collaboration with different CRC projects. The bioinformatic analysis was conducted in part by Matthias Schmitz and Johannes Schöneich (both B01). Body imaging was done with the help of Sarah Schraven (Q01) under the supervision of Prof. Fabian Kiessling. Quantification of serum metabolites was performed in the group of Prof. Martin von Bergen (A05).