New CRC publication in Nature:
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease
Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) leading to AAT misfolding, hepatic accumulation and consecutive hepatotoxic stress. To improve our understanding of proteotoxicity, Rosenberger et al including Pavel Strnad (A03) employed a novel proteomic technique to study the consequences of AAT accumulation as well as of different protein aggregates. Their data allow an unprecedented insight into the biologic context of this widespread phenomenon that constitutes the hallmark of multiple human disorders.