New CRC publication:
Programmed and environmental determinants driving neonatal mucosal immune development
Natalia Torow, one of our CRC1382 ‘Rising Stars’ and PI Mathias Hornef (project B01) have published this review article in Immunity.
‘In this paper we demonstrate that despite early microbial colonization the delayed maturation of follicle associated epithelial M cells and Peyer’s patch antigen presenting cells determines the pace for the postnatal establishment of the homeostatic mutual interaction between the enteric microbiota and the mucosal immune system seen in the adult mouse. The CRC1382 provided the critical infrastructure for this highly collabortive work and we are now working on connecting the intestinal and hepatic postnatal immune development to better understand the unique state of neonatal immunity.’