Main Topics of the Symposium

  • Diseases of the Gut-Liver Axis
  • Microbiome and Gut-Liver Diseases
  • Modelling the Gut-Liver Axis and Metabolism
  • Immune Circuits in the Gut-Liver Axis
  • The Role of Bile Acids in the Gut-Liver Axis

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Thursday 6 Oct 2022

8:00 – 9:00 Registration and coffee

No workshops in this session.

9:00 – 9:15 Welcome address

9:15 – 11:30 Session 1: Diseases of the gut-liver axis

chair persons: Marie Berres and Mathias Hornef

‘Nonbacterial Kingdoms of the Gut Microbiota and Alcohol-Associated Liver Disease’

Bernd SchnablSuperC (RWTH Aachen University)

UC San Diego, USA

Thu 9:15 – 11:30

‘Primary sclerosing cholangitis: immune dysregulation in disease   pathogenesis‘

Christoph SchrammSuperC (RWTH Aachen University)

UKE Hamburg, Germany

Thu 9:15 – 11:30

‘Gut-liver-axis and decompensation of liver cirrhosis’

Jonel TrebickaSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Thu 9:15 – 11:30

‘Immunogenetic approaches to identify the culprit antigen in inflammatory bowel diseases’

Andre FrankeSuperC (RWTH Aachen University)

Kiel University, Germany

Thu 9:15 – 11:30

‘Lost in transl(oc)ation: Human peritoneal immunity in cirrhosis’

Tony BrunsSuperC (RWTH Aachen University)

CRC1382, RWHT Aachen University

Thu 9:15 – 11:30

‘Macrophage heterogeneity in liver diseases’

Frank TackeSuperC (RWTH Aachen University)

CRC1382, Charité Berlin, Germany

Thu 9:15 – 11:30

‘The liver-gut axis in NASH-HCC’

Mathias HeikenwälderSuperC (RWTH Aachen University)

DKFZ Heidelberg, Germany

Thu 9:15 – 11:30

11:30 – 12:00 Coffee Break

No workshops in this session.

12:00 – 13:00 Short talks

chair persons: Heidi Noels and Christian Liedtke

Various presentations

PhD Students of CRC1382SuperC (RWTH Aachen University)

Thu 12:00 – 13:00

13:00 – 13:40 Lunch break

No workshops in this session.

13:45 – 15:15 Guided city tour

No workshops in this session.

15:15 – 15:45 Coffee Break

No workshops in this session.

15:45 – 18:00 Session 2: Microbiome and gut-liver diseases

Chair persons: Angela Schippers and Oliver Pabst

‘Causality or association of gutmicrobiota and their metabolites in human NAFLD-NASH;  potential for  new diagnostic and therapeutic leads’

Max NieuwdorpSuperC (RWTH Aachen University)

Amsterdam UMC, The Netherlands

Thu 15:45 – 18:00

‘Exploring the gut-liver axis in cancer cachexia’

Laure BindelsSuperC (RWTH Aachen University)

Université catholique de Louvain, Brussels, Belgium

Thu 15:45 – 18:00

‘Modulation of the Gut-Liver Axis through Fecal Microbiota Transfer’

Maria VehreschildSuperC (RWTH Aachen University)

Frankfurt University, Germany

Thu 15:45 – 18:00

‘Short-chain fatty acids and advanced chronic liver disease’

Rubén FrancésSuperC (RWTH Aachen University)

Alicante University Hospital, Spain

Thu 15:45 – 18:00

‘The gut liver axis during early life’

Mathias HornefSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Thu 15:45 – 18:00

18:00 – 19:30 Poster session

Reception with finger food and drinks

20:00 – 23:00 Dinner

invited speakers and PIs of CRC1382
Followed by open bar at Hotel Motel one, Aachen

Friday 7 Oct 2022

8:00 – 9:00 Registration and coffee

No workshops in this session.

9:00 – 9:05 Welcome

No workshops in this session.

9:05 – 12:45 Session 3: Immune circuits in the gut-liver axis

Chair persons: Vuk Cerovic and Pavel Strnad

Coffee break in between

‘Dendritic cells as cellular targets of gut-liver communication in chronic liver disease and hepatocellular carcinogenesis’

Marie BerresSuperC (RWTH Aachen University)

CRC 1382, RWTH Aachen University

Fri 9:05 – 12:45

‘Development and function of the innate immune system’

Andreas DiefenbachSuperC (RWTH Aachen University)

Charité Berlin, Germany

Fri 9:05 – 12:45

‘Growing, flowing and sugar-coating in intestinal IgA responses’

Emma SlackSuperC (RWTH Aachen University)

ETH Zurich, Switzerland

Fri 9:05 – 12:45

‘Role of bacterial membrane vesicles along the gut-liver axis: Implications for novel therapeutic targets’

Claudia GüntherSuperC (RWTH Aachen University)

UK Erlangen, Germany

Fri 9:05 – 12:45

‘The gut liver axis in early life and as a tool for studying B cell specificity’

Andrew MacphersonSuperC (RWTH Aachen University)

Bern University Hospital, Switzerland

Fri 9:05 – 12:45

‘Topology and function of secretory antibodies in gut-liver communication’

Oliver PabstSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Fri 9:05 – 12:45

‘Unravelling the cell-cell interactions forming the foundation of the macrophage niche’

Martin GuillaumsSuperC (RWTH Aachen University)

Ghent University, Belgium

Fri 9:05 – 12:45

12:45 – 13:30 Lunch break

No workshops in this session.

13:30 – 15:30 Session 4: Metabolism and modelling the gut-liver axis

Chair persons: Heidi Noels and Thomas Clavel

‘Control of bile acid metabolism within the gut-liver-axis’

Christian TrautweinSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Fri 13:30 – 15:30

‘Physiologically-based computational models of bile acid metabolism’

Lars KüpferSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Fri 13:30 – 15:30

‘Quantitative Lipidomics – methods to analyze the Gut-Liver Axis’

Gerhard LiebischSuperC (RWTH Aachen University)

University Hospital Regensburg, Germany

Fri 13:30 – 15:30

15:00 – 15:30 Coffee Break

No workshops in this session.

15:30 – 17:30 Session 5: The role of bile acids in gut-liver crosstalk

‘Bile salt signaling and homeostasis in the regenerating liver’

Frank SchaapSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Fri 15:30 – 17:30

‘Functional imaging of bile acid transport in liver diseases’

Jan HengstlerSuperC (RWTH Aachen University)

TU Dortmund, Germany

Fri 15:30 – 17:30

‘Hepatoprotective roles of the Bile Acid Receptor TGR5’

Thierry TordjmannSuperC (RWTH Aachen University)

Université Paris Sud, Orsay, France

Fri 15:30 – 17:30

‘Synthetic communities of cultured gut bacteria enables the functional study of bile acid metabolism in health and disease’

Thomas ClavelSuperC (RWTH Aachen University)

CRC1382, RWTH Aachen University

Fri 15:30 – 17:30

17:00 – 17:10 Closing remarks and farewell