New CRC publication in Nature: Deep Visual Proteomics maps proteotoxicity in a genetic liver disease Alpha1-antitrypsin deficiency arises due to mutations in alpha1-antitrypsin (AAT) leading to AAT misfolding, hepatic accumulation and consecutive hepatotoxic stress. To improve our understanding of proteotoxicity, Rosenberger et al including Pavel Strnad (A03) employed a novel proteomic technique [...]

New CRC publication in Liver International: Alpha-1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid-Inducible Manner Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder that results in the accumulation of misfolded AAT protein in liver cells, causing chronic liver injury. Principal investigators (PIs) Prof. Pavel Strnad and Dr. Nurdan Guldiken from [...]