By Catherine Gonzalez|2025-05-22T14:56:28+02:0022.05.2025|
Gut-Liver Axis in the News On May 14th, 2025, NANO met with scientists from the CRC 1382 Gut-Liver Axis at RWTH Aachen University Hospital to get a look at the exciting research being done with a focus on Organ Crosstalk. Take a look at the video here. The segment on the CRC [...]
By Betül Aycicek|2024-08-06T12:04:33+02:0025.03.2024|
Publication in Hepatology Communications Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR Bile salts are an important means of communication in the organ crosstalk between gut and liver. PhD student Ümran Ay, Frank Schaap, Steven Olde Damink [...]
By hherbrand@ukaachen.de|2024-08-06T12:05:55+02:0007.02.2024|
Publication in the Journal of Experimental Medicine Salmonella infection: Non-professional efferocytosis contributes to barrier integrity in the neonate The immune system and the intestinal barrier of neonates and adult organisms are fundamentally different. Therefore, infections with the enteropathogen Salmonella have a different course and outcome [...]
By hherbrand@ukaachen.de|2024-02-06T17:47:12+01:0006.02.2024|
“Our Microbiome – the invisible extinction“ - Special cinema screening with discussion, moderated by CRC1382 PIs Oliver Pabst and Tom Clavel In the documentary "Our Microbiome - The Invisible Extinction", filmmakers Steven Lawrence and Sarah Schenck accompany the two microbiologists Gloria Dominguez-Bello and her husband, Martin Blaser who [...]
By hherbrand@ukaachen.de|2023-06-02T13:39:00+02:0019.05.2023|
A reason to celebrate: The German research Foundation (DFG) approves second funding period for our CRC! On 17 May 2023, the DFG Senate decided to support our CRC for a second funding period of four more years (DFG, German Research Foundation - Press Releases). We [...]
By hherbrand@ukaachen.de|2023-04-27T17:43:58+02:0027.04.2023|
nature reviews gastroenterology & hepatology: 'Gut-liver axis: barriers and functional circuits' On behalf of our entire consortium, our spokesperson Oliver Pabst (B06, Q04), Mathias W. Hornef (B01, Q03), Frank Schaap (A07), Thomas Clavel (A05, Q02), Vuk Cerovic (B03) and Tony Bruns (B07) have summarised central [...]
By hherbrand@ukaachen.de|2023-04-27T17:41:45+02:0027.04.2023|
New CRC publication: Programmed and environmental determinants driving neonatal mucosal immune development Natalia Torow, one of our CRC1382 'Rising Stars' and PI Mathias Hornef (project B01) have published this review article in Immunity. 'In this paper we demonstrate that despite early microbial colonization the delayed [...]
By hherbrand@ukaachen.de|2023-04-27T16:40:44+02:0027.04.2023|
New CRC publication: Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression PIs from external project B05 at Charité Berlin, Adrien Guillot as first author and Frank Tacke as last author, succeeded in publishing their results in the [...]
By hherbrand@ukaachen.de|2023-01-06T13:20:52+01:0006.01.2023|
New CRC publication: Blood Endotoxin Levels as Biomarker of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis This publication in Clinical Gastroenterology and Hepatology is the result of intensive collaboration of scientists in our CRC. Scientists from 5 CRC projects participated in this study: [...]
By hherbrand@ukaachen.de|2023-01-04T21:32:30+01:0022.11.2022|
New CRC publication: Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency Promising results on a phase 2 clinical study entitled "Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency" was recently published in The New England Journal of Medicine. Alpha1-antitrypsin deficiency is an inherited, proteotoxic disorder [...]
