By Anne Eisele|2025-04-11T11:30:26+02:0011.04.2025|
New CRC publication in Gut: Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming In this study, the CRC1382 team working on project B05, revealed the roles of the cholangiocyte-derived ORM2 protein in re-shaping the portal niche during liver diseases. Cholangiocytes are epithelial cells lining the [...]
By Anne Eisele|2025-01-09T10:22:39+01:0009.01.2025|
New CRC publication in Liver International: Alpha-1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid-Inducible Manner Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder that results in the accumulation of misfolded AAT protein in liver cells, causing chronic liver injury. Principal investigators (PIs) Prof. Pavel Strnad and Dr. Nurdan Guldiken from [...]
By Anne Eisele|2025-01-09T09:39:43+01:0009.01.2025|
New CRC publication in PNAS: Salmonella infection accelerates postnatal maturation of the intestinal epithelium The postnatal establishment of metabolic, host–microbial, and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Tissue damage during this “neonatal window of opportunity” may disrupt these processes explaining human epidemiological data associating [...]
By Anne Eisele|2024-08-08T09:57:55+02:0008.08.2024|
New CRC publication in Liver International: Using machine learning and big data to understand the gut liver axis Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one third of the population and can progress to much more severe states of liver damage influenced by the interplay of lifestyle, genes and environment. One [...]
By Anne Eisele|2024-08-08T09:52:24+02:0009.07.2024|
New CRC publication in Advanced Science: Dissecting Acute Drug-Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver-On-A-Chip Model Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease affecting more than one quarter of humankind. This study by Adrien Guillot, Frank [...]
By Betül Aycicek|2024-08-06T12:04:33+02:0025.03.2024|
Publication in Hepatology Communications Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR Bile salts are an important means of communication in the organ crosstalk between gut and liver. PhD student Ümran Ay, Frank Schaap, Steven Olde Damink [...]
By hherbrand@ukaachen.de|2024-08-06T12:05:55+02:0007.02.2024|
Publication in the Journal of Experimental Medicine Salmonella infection: Non-professional efferocytosis contributes to barrier integrity in the neonate The immune system and the intestinal barrier of neonates and adult organisms are fundamentally different. Therefore, infections with the enteropathogen Salmonella have a different course and outcome [...]
By hherbrand@ukaachen.de|2023-06-02T13:39:00+02:0019.05.2023|
A reason to celebrate: The German research Foundation (DFG) approves second funding period for our CRC! On 17 May 2023, the DFG Senate decided to support our CRC for a second funding period of four more years (DFG, German Research Foundation - Press Releases). We [...]
By hherbrand@ukaachen.de|2023-04-27T17:43:58+02:0027.04.2023|
nature reviews gastroenterology & hepatology: 'Gut-liver axis: barriers and functional circuits' On behalf of our entire consortium, our spokesperson Oliver Pabst (B06, Q04), Mathias W. Hornef (B01, Q03), Frank Schaap (A07), Thomas Clavel (A05, Q02), Vuk Cerovic (B03) and Tony Bruns (B07) have summarised central [...]
By hherbrand@ukaachen.de|2023-04-27T17:41:45+02:0027.04.2023|
New CRC publication: Programmed and environmental determinants driving neonatal mucosal immune development Natalia Torow, one of our CRC1382 'Rising Stars' and PI Mathias Hornef (project B01) have published this review article in Immunity. 'In this paper we demonstrate that despite early microbial colonization the delayed [...]
