By Anne Eisele|2025-01-09T10:22:39+01:0009.01.2025|
New CRC publication in Liver International: Alpha-1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid-Inducible Manner Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disorder that results in the accumulation of misfolded AAT protein in liver cells, causing chronic liver injury. Principal investigators (PIs) Prof. Pavel Strnad and Dr. Nurdan Guldiken from [...]
By Anne Eisele|2025-01-09T09:39:43+01:0009.01.2025|
New CRC publication in PNAS: Salmonella infection accelerates postnatal maturation of the intestinal epithelium The postnatal establishment of metabolic, host–microbial, and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Tissue damage during this “neonatal window of opportunity” may disrupt these processes explaining human epidemiological data associating [...]
By Anne Eisele|2024-08-08T09:57:55+02:0008.08.2024|
New CRC publication in Liver International: Using machine learning and big data to understand the gut liver axis Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one third of the population and can progress to much more severe states of liver damage influenced by the interplay of lifestyle, genes and environment. One [...]
By Anne Eisele|2024-08-08T09:52:24+02:0009.07.2024|
New CRC publication in Advanced Science: Dissecting Acute Drug-Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver-On-A-Chip Model Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease affecting more than one quarter of humankind. This study by Adrien Guillot, Frank [...]
By Betül Aycicek|2024-08-06T12:04:33+02:0025.03.2024|
Publication in Hepatology Communications Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR Bile salts are an important means of communication in the organ crosstalk between gut and liver. PhD student Ümran Ay, Frank Schaap, Steven Olde Damink [...]
By hherbrand@ukaachen.de|2024-08-06T12:05:55+02:0007.02.2024|
Publication in the Journal of Experimental Medicine Salmonella infection: Non-professional efferocytosis contributes to barrier integrity in the neonate The immune system and the intestinal barrier of neonates and adult organisms are fundamentally different. Therefore, infections with the enteropathogen Salmonella have a different course and outcome [...]
By hherbrand@ukaachen.de|2023-04-27T17:43:58+02:0027.04.2023|
nature reviews gastroenterology & hepatology: 'Gut-liver axis: barriers and functional circuits' On behalf of our entire consortium, our spokesperson Oliver Pabst (B06, Q04), Mathias W. Hornef (B01, Q03), Frank Schaap (A07), Thomas Clavel (A05, Q02), Vuk Cerovic (B03) and Tony Bruns (B07) have summarised central [...]
By hherbrand@ukaachen.de|2023-04-27T17:41:45+02:0027.04.2023|
New CRC publication: Programmed and environmental determinants driving neonatal mucosal immune development Natalia Torow, one of our CRC1382 'Rising Stars' and PI Mathias Hornef (project B01) have published this review article in Immunity. 'In this paper we demonstrate that despite early microbial colonization the delayed [...]
By hherbrand@ukaachen.de|2023-04-27T16:40:44+02:0027.04.2023|
New CRC publication: Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression PIs from external project B05 at Charité Berlin, Adrien Guillot as first author and Frank Tacke as last author, succeeded in publishing their results in the [...]
By Catherine Gonzalez|2023-03-07T14:31:32+01:0007.03.2023|
LaTeX: Allowing you to focus on content, not appearance. Logo taken from: www.latex-project.org What is it? LaTeX is a software system used to prepare documents from smaller documents such as resumes and articles to large documents such as books. LaTeX is not the same as Microsoft Word! [...]
